Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder. Chen JJ, Flanagan EP, Bhatti MT, et al. Neurology 2020; 95:e111-e120. Abstract Objective Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in […]
Intravenous fibrinolysis for central retinal artery occlusion: a cohort study and updated patient-level meta-analysis. Mac Grory B, Nackenoff A, Poli S, et al. Stroke 2020; 51:2018-2025. Abstract Background Central retinal artery occlusion results in sudden, painless, usually permanent loss of vision in the affected eye. There is no proven, effective treatment to salvage visual acuity […]
A critical part of history taking in medicine is establishing the occupation of the patient. This is because occupational activities and work place exposures are often major contributors to the disease. Furthermore, at the end of the medical process, the eventual diagnosis may have an impact on the patient’s ability to return to work. To be relevant, the occupational history must be exhaustive– it must establish current and past occupations, the tasks carried out, the risk of toxic exposure, and the use of personal protective equipment (PPE). The occupational history is so important to neurology that a whole subspecialty, occupational neuroscience, has emerged to evaluate “the effects of complex environmental and occupational exposure on working people”.
Previously an occupational hazard restricted to professional typists, carpal tunnel syndrome (CTS) now threatens anyone who uses a computer. CTS develops when the median nerve is entrapped at the wrist, and it manifests as weakness and sensory disturbances over the thumb, the index finger, the middle finger, and half of the ring finger. Whilst desk work is the main risk of CTS, manual workers are not spared the peril because the occupations that increase the risk of CTS include assembly work, food processing and packing, and the use of hand-help powered vibratory tools. And, by the way, vibrating tools also predispose to cubital tunnel syndrome, entrapment of the ulnar nerve at the elbow which presents as weakness and sensory impairment of the little finger, and half of the ring finger (you now know why it was chosen for the wedding ring). Cubital tunnel syndrome, again by the way, also happens to be an occupational hazard of truck drivers, baseball pitchers, and golfers. Just saying.
An almost iconic neurological occupational risk-relationship is the association of welding and Parkinson’s disease (PD). Along with the related tasks of galvanizing and grinding, welding releases fumes of manganese (Mn), the metal that is suspected to be the PD-trigger in this case. As with pesticides, the risk appears to be proportional to the degree of exposure. But unlike pesticides, the reported PD risk of manganese is equivocal because some studies have not found any relationship between welding fumes and PD; indeed one found an inverse relationship between the two, reporting that welding reduces the risk of PD. Surely there are no fumes without fire, but in spite of this minor controversy, or because of it, neurologists are forever vigilant for manganese fumes when they make a diagnosis of PD; they are aware, after all, that only more data will clear the fumes. As an addendum, many other occupations, from teaching to computer programming, reportedly increase the risk of developing PD – presumably because of occupational stress!
Just as welding conferred notoriety on manganese, so has smelting endowed lead (Pb) with infamy. And the metal’s neurological ignominy is the peripheral neuropathy it evokes. The classical but rarer form of lead neuropathy, is a subacute motor neuropathy which is a manifestation of lead-induced porphyria. Far more common is a chronic sensory neuropathy which is considered to be the direct result of lead toxicity. Beyond neuropathy, chronic lead exposure has garnered disrepute for its reported links with motor neurone disease (MND), although this risk association is contested. In fairness to Pb, other periodic table elements such as thallium(Tl) and arsenic (As) also pose significant occupational risks of neuropathy. And whilst still on metals, it is worth pointing out the report that occupational exposure to iron (Fe) may be a risk factor for meningiomas. Dmitri Mendeleev must be turning in his grave!
Neurologists, particularly of the movement disorder fraternity, listen to the occupational history of their patients with very keen ears, which literally prick up when they hear that the patient is a musician. This is because a large swathe of musical instruments predispose musicians to career-threatening task-specific dystonia, a form of dystonia which targets muscles that are most frequently exerted, especially in performing delicate actions. Whilst this umbrella diagnosis embraces such non-musical disorders as writer’s cramp, runner’s dystonia, and croupier’s cramp, it is musician’s dystonia that constitutes the widest spectrum of task-specific dystonia. And the reason is not far-fetched: playing musical instruments professionally requires the repetitive performance of very exquisite motor skills over long periods of time. Initially, the dystonia is only evident whilst playing the musical instrument, but it eventually manifests during unrelated tasks, and even at rest. Thediversity of symptoms of musician’s dystonia is rivalled only by the number of instruments in the music ensemble, ranging fromfinger incoordination to upper lip tremor. Singers are also at risk ofdysphonia, a form of voice dystonia which they share with teachers, telemarketers and aerobic instructors – all potential victims of hoarseness and voice fatigue.
Unsurprisingly, competitive sports takes a heavy toll on the nervous system. At the fairly benign end of the spectrum is the compression of nerves, the innocent victims of grotesquely enlarged, almost mythically Herculean, muscles. Many nerves may be stretched or trapped by a long list of risky sports which includes archery, ballet, baseball, basketball, bowling, football, golf, hockey, tennis, weightlifting, gymnastics, and wrestling. And the classic sport-related nerve entrapment is that of the long thoracic nerve which manifests as scapular winging. Unfortunately, many sporting-related neurological hazards lie at the malign end of the spectrum, with such appalling diseases as chronic traumatic encephalopathy (CTE) from repetitive contact sports; Parkinson’s disease from the boxing related head injuries; and motor neurone disease (MND) especially fromprofessional football. As with most such risks, the evidence for some sports-related neurological hazards is often anecdotal, but very difficult to dismiss in a neurology clinic.
This is, of course, a no brainer as every shift worker knows. Sleep disruption is the most prominent, but by far not the most serious hazard of burning the midnight candle at work. It is common knowledge that shift work reduces alertness, thereby compromising work performance. But more seriously, shift work increases the risk of several neurological disorders such as stroke, epilepsy, Parkinson’s disease (PD), Alzheimer’s disease (AD), and even multiple sclerosis (MS). As if these are not enough, shift work also predisposes to malignancies such as breast cancer and colon cancer, apart from impairing the function of many organs. Indeed the number of disorders now grouped under the remit of shift work sleep disorder (SWSD) is mind-numbing (apologies, I can’t conjure up a better pun). The reason shift work is such a medical nuisance is that it disrupts the brain’s critical circadian rhythm, thereby impairing the production of melatonin, a hormone that plays a hugely critical neuroprotective role. So think twice before taking that next lucrative night shift!
In our continuing zeal to maintain a grip on all of neurology, We regularly add to our already exhaustive database of checklists. As a taster of what we have recently done, Below are 15 brand new checklists expanding our horizon. *** Acute amnestic syndromes Alzheimer’s disease preventative measures Antiplatelet resistance: causes Antiplatelet resistance: management Encephalocraniocutaneous […]
It is difficult to really say when neuroscience began, but most sources trace the first account of the nervous system to what is now known as the Edwin Smith papyrus; this is an Egyptian text written around 1700 B.C which documents surgical procedures for brain trauma. Since then, neuroscience breakthroughs have come at breakneck speed. The sources I have consulted for this blog post, referenced at the end, name innumerablediscoveries made by countless innovators. To attempt to put a number to the most important breakthroughs will therefore be a well-nigh impossible task. So I came up with the idea of chunking key discoveries under distinct sections or systems of the nervous system.
But even this plan to chunk key breakthroughs came with strong challenges. For example, it is not always clear when a discovery was first made, or who crossed the finishing line first. This is because there are often several contenders in a tight race to the finish, and only a few discoveries were definite one-manparadigm-changing works. On the contrary, most discoveries were made by two or three pioneers working in a creative partnership, or by larger groups of people working in innovative collaborations. A further challenge was establishing what or where the finishing line was, as this is not always well-defined; this is understandable because most scientific advances were made over centuries, in small incremental steps, in a gradual progression from basic observation to complex synthesis.
To overcome these challenges, I have avoided too much emphasis on the ‘who first‘ conundrum that drives, and sometimes mires, science. I have also side-stepped the ‘when first‘ problem by noting only a few dates just to maintain some sense of chronology. I did a lot of picking and choosing for this post, and it is inevitable that somebody’s favourite discovery, or discoverer, would be missing; take heart and exult in the collective effort that has gone into these monumental breakthroughs in the history of neuroscience.
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Cerebrospinal fluid (CSF)
It is difficult to pinpoint who first described the cerebrospinal fluid (CSF) circulation but Nicolo Massa, Lewis Weed, Gustav Retzius, Francois Magendie and Albrecht von Haller have all been cited. The names associated with accurately describing the constituents of CSF are William Halliburton and William Mestrezat. Franciscus de la Boe Sylvius is credited with describing the aqueduct of Sylvius, and Alexander Monro for describing the foramen of Monro. Antonio Pacchioni discovered arachnoid granulations, whilst Guilio Cesare and Thomas Willis are credited for describing the anatomy and function of the choroid plexus. The accurate description of the blood brain barrier has been attributed to both Max Lewandowsky and Paul Erlich.
Cerebral localisation of functions has always been, and continues to be, a key neuroscience task. As brain functions become increasingly recognised as network-based, rather than region-based, cerebral localisation is taking more of a back seat in neuroscience. But it is still worthwhile to acknowledge the pioneers who identified key brain areas. Paul Broca is credited with the first description of the cortical speech area, whilst motor function localisation is traced to the works of Eduard Hitzig, Gustav Fritsch, David Ferrier, and Victor Horsley. The classification of cerebral areas into 52 parts was done by Korbinian Brodmann, whilst it was neurosurgeon Wilder Penfield who defined the cortical maps of the motor and sensory homunculus.
Both Rudolph Virchow and Heinrich Müller are credited with describing neuroglia. The credit for classifying these into microglia and oligodendroglia goes to Pio del Rio Hortega, whilst that for describing dendrites and axons goes to Otto Friedrich Karl Deiters. Camillo Golgi introduced the critical silver nitrate method of staining nerve cells, a technique advanced by Santiago Ramon y Cajal, who developed the gold chloride-mercury method for staining astrocytes. The description of the synapse is attributed to the truly great Charles Scott Sherrington. W. Bevan Lewis, Vladimir Betz and Johannes Purkinje have all been credited with describing the giant motor nerves of the cortex.
Rufus of Ephesus is named as the first person to describe and name the optic chiasma. Other cranial nerve achievements are the discovery of the tenth cranial nerve by Marinus, and the description of seven cranial nerves by Rhazes. The trochlear and abducens nerves were described by Gabriele Falloppio, and it was Samuel Thomas von Soemmerring who introduced the current classification of the twelve cranial nerves.
The credit for distinguishing between myelinated and unmyelinated nerves goes to Robert Remak, whilst the credit for describing myelin formation goes to Theordor Schwann. It was Louis-Antoine Ranvier who described the gaps between myelin sheaths called the nodes of Ranvier. The different types of sensory nerves were described by Herbert Gasser, and it was Friedreich Merkel who described the sensory receptors now known as Merkel corpuscles. Credit for describing the cutaneous distribution of sensory nerves goes to Henry Head, and it was Francois Magendie who recognised the different functions subserved by the dorsal and ventral nerve roots of the spinal cord.
The early understanding of how nerves function has a lot to do with the description by Hermann Helmholtz of the electrical nerve impulse velocity. The resting membrane potential was described by Julius Bernstein and Walter Nernst, whilst Keith Lucas and Edgar Adrian measured peripheral nerve impulses, Adrian going on to confirm that nerve impulses are all or none. Alan Hodgkin and Andrew Huxley are credited with describing the mechanisms of action potentials, whilst Joseph Erlanger and Herbert Spencer Gasser described the function of single nerve fibers.
Whilst nerve function is electrical, it is chemicals that bridge the gap between nerves. The chemical neurotransmitters of peripheral nerves, norepinephrine and acetylcholine, were isolated by George Barger and Henry Dale. The credit for establishing chemical neurotransmission between nerves and muscles, at the neuromuscular junction, goes to Otto Loewi‘s dream-inspired work on Vagusstoff. The discovery of the central nervous system neurotransmitter GABA is credited to Eugene Roberts and Jorge Awapara. Most of the later work on neurotransmitters were made by Julius Axelrod, Bernard Katz and Ulf Svante von Euler, and the credit for elucidating the function of ion channels goes to Erwin Neher and Bert Sakmann.
The visual system is fundamental to neuroscience, and credit for describing its mechanism goes to Ragnar Granit, Halden Hartline and George Wald. The merit for elucidating the details of visual processing goes to David Hubel and Torsten Wiesel. The sense of smell is similarly important, and initial work on this was made by David Ferrier, but it is to Linda Buck and Richard Axel that kudos go for discovering odour receptors, and for describing the configuration of the olfactory system.
The acclaim for establishing the anatomical foundations of memory goes to Brenda Milner for her work on Patient HM. It is however Eric Kandel who has the honour of working out the functional process of memory formation. The gate control theory of pain was established by Ronald Melzack and Patrick Wall, whilst credits for establishing the nature of prion diseases go to the lively Daniel Carleton Gajdusek, and the indefatigable Stanley Prussiner.
The brain’s positioning system was discovered by John O’Keefe, Edvard Moser, and May-Britt Moser. Cedit for discovering mirror neurones goes to Giacomo Rizzolatti, whilst Rita Levi-Montalcini and Stanley Cohen were the first to isolate nerve growth factor.
Thomas Willis, Henry Duret and Johann Heubner first described the arterial circulation of the brain, whilst the electrical brain wave activity of the brain was first recorded by Hans Berger, incidentally when he was investigating telepathy.
And so ends this rapid whizz through the annals of neuroscience. This is just the condensed tip of the iceberg; to learn more about the fascinating giants who defined the glorious history of neuroscience, you may wish to slowly digest the following sources:
As weird as it may sound, many of the reports being anecdotal, there are actually grains of truth and crumbs of evidence supporting the claim that pets are not just for Christmas. For example, there is a trail of research studies confirming the effectiveness of seizure detecting dogs; one paper specifically reports that they enabled 90% of subjects toreduce their seizure frequency by 34-50%. Although the time from seizure-detection to the actually seizure varies wildly, from 10 seconds to 5 hours before the epileptic attack, there seems to be enough time in most cases for the subject to take preventative measures.
But not all dogs are as skilled in the act as others, and your best bet is on alerting dogs which have a stronger bond with their owners. And if you want to pick a dog for its seizure-detecting skills, go for one that scores high in motivation…and low in neuroticism. This is important because the ability of dogs to detect seizures is not always benign; they are known to respond by attacking the subject or their helpers as part of an untrained fight or flight reaction. It is important therefore that seizure-alerting dogs are trained not to be stressed, and to respond appropriately.
But what are dogs actually detecting when they detect seizures? The conventional theory is that they are responding to subtle changes in behaviour; this may therefore explain why dogs can also warn of impending non-epileptic attacks, an observation that has been duplicated in another paper. The other possibility however is that the dogs are detecting disease-specific odours. This concept should not be surprising because, for example with infections, it has been shown that endotoxins induce a detectable aversive body odour. Similarly with liver disease, exhaled breath is already being considered in sorting out differential diagnoses. One premise behind the disease-odour hypothesis is the existence of disease-specific volatile organic compounds (VOCs). It feels all so exciting-no wonder there is now a well-developed scientific field of exhaled air analytics.
But as with all things in life, and particularly in science, here are always the naysayers, the gatecrashers to the party. And so it is that, with the case of seizures, there are those who are not convinced that pets possess the guile to pick up seizures. For example, in a small study of 3 subjects in an epilepsy monitoring unit, Rafael Ortiz and Joyce Liporace, reporting in the journal Epilepsy and Behaviour, found that seizure alert dogs were not effective in predicting seizures. In another paper published in the journal Epilepsy Research, titled Can seizure-alert dogs predict seizures?, Stephen Brown and Laura Goldstein observed that there is “no rigorous data” to support the assertion that seizure alert dogs accurately predict seizures. Another detailed review in Plos One in 2018, by Amélie Catala and colleagues, concluded that appropriate empirical evidence that dogs can alert or respond to epileptic seizures is still missing.
But as the overused cliché goes, absence of evidence is not the evidence of absence. So how can we prove that dogs are indeed detecting seizure-specific odours? This is the task Amélie Catala and her colleagues also set out to accomplish when they made 5 dogs to sniff the odours obtained from 5 people with epilepsy. They tasked the dogs to tell apart the odours obtained around the time of the subjects’ seizures, from the odours obtained at other times when there were no proximate seizures. Reporting their findings in Science Report in 2019, under the title Dogs demonstrate the existence of an epileptic seizure odour in humans, they found that all the 5 dogs easily distinguished the seizure-related odours from the non-seizure related odours. But the small scale of the trial (were there just not enough dogs to go round?) justifies the authors’ call for larger trials to confirm their findings.
This is clearly still a grey area in epilepsy management, but one with a high potential if explored further. Are there any pet-loving neurologists willing to get in on the act? Do come along with your pets!
Medicine is as much defined by diseases as by the people who named them. Neurology particularly has a proud history of eponymous disorders which I discussed in my other neurology blog, Neurochecklists Updates, with the title 45 neurological disorders with unusual EPONYMS in neurochecklists. In many cases, it is a no brainer that Benjamin Duchenne described Duchenne muscular dystrophy, Charle’s Bell is linked to Bell’s palsy, Guido Werdnig and Johann Hoffmann have Werdnig-Hoffmann disease named after them. Similarly, Sergei Korsakoff described Korsakoff’s psychosis, Adolf Wellenberg defined Wellenberg’s syndrome, and it is Augusta Dejerine Klumpke who discerned Klumpke’s paralysis. The same applies to neurological clinical signs, with Moritz Romberg and Romberg’s sign, Henreich Rinne and Rinne’s test, Joseph Babinski and Babinski sign, and Joseph Brudzinski with Brudzinki’s sign.
Yes, it could become rather tiresome. But not when it comes to diseases which, for some reason, never had any names attached to them. Whilst we can celebrate Huntington, Alzheimer, Parkinson, and Friedreich, who defined narcolepsy and delirium tremens? This blog is therefore a chance to celebrate the lesser known history of neurology, and to inject some fairness into the name game. Here then are 25 non-eponymous neurological diseases and the people who discovered, fully described, or named them.
By A. F. Dressler – Festschrift zum 70. Geburtstag Dr. Woldemar Kernig’s: Von Verehrern und Schülern herausgegeben als Festnummer der St. Petersburger medicinischen Wochenschrift St. Petersburger medizinische Wochenschrift, Bd. 35, Nr. 45. (1910), Public Domain, Link
This post continues our long tradition of highlighting the catchiest neurology titles out there in the universe of the neurological literature. Looking back, I have done quite a few posts on this topic, but the fountain of catchy neurology titles is yet to dry up. But before going on, you may want to catch up with our previous posts on this theme:
This is the title of a 2019 editorial in the journal Epilepsy Currents, and FIRES here refers to febrile infection related epilepsy syndrome (FIRES). FIRES is itself a form of new onset refractory status epilepticus (NORSE) in which there is associated fever. NORSE and FIRES are notoriously resistant to treatment, and the editorial points out the abject failures of steroids, IVIg, and plasma exchange, and the limited benefit of ketogenic diet and anakinra. This is where the hose comes in: it is the interleukin‐6 receptor inhibitor tocilizumab; the original research paper, published in the journal Annals of Neurology in 2018, reported that seven patients treated with Tocilizumab had very good outcomes. Take home messages: perhaps Tocilizumab is the right fire-extinguisher for this blazing inferno, and there must be an acronym-generating machine in the epilepsy universe!
The full title of this paper is “Dosing interval of natalizumab in MS: do good things come to those who wait?” It comes from a 2019 issue of the journal Neurology, and it is itself an editorial on a paper in the same journal which touted the benefits of extended dosing interval of natalizumab in multiple sclerosis. That paper showed that the risk of progressive multifocal leukoencephalopathy (PML) can be reduced by reducing the frequency of Natalizumab infusions. The authors used a 6 weekly, rather than the conventional 4 weekly, dosing interval of Natalizumab, and their gamble had paid off; they reported a “remarkable” risk reduction of developing PML by 88-99%. Enough justification for a catchy title, and proof that procrastination pays off…sometimes.
The full, more intriguing, title of this paper is “Looking for Mr(s) Right: Decision bias can prevent us from finding the most attractive face”. Something for incurable romantics. Published in the journal Cognitive Psychology in 2019, the paper revealed that, when it comes to picking partners, we stick at it much longer than we do when we make other decisions, somehow believing that the best has been saved for the last. The participants in the study kept looking out for “rare, highly-attractive faces“, so much so that many of them couldn’t make any choice at all. Proof that Mr and Mrs Right are hard to find…if they exist at all!
The full title of this paper is “Don’t fear the reefer-evidence mounts for plant-based cannabidiol as treatment for epilepsy”. Published in Epilepsy Currents in 2019, it set out to reassure clinicians that cannabis is OK…sort of. The paper reports the findings of a double-blind study of 225 people with Lennox-Gastaut syndrome (LGS), the severe epilepsy disorder which manifests with dangerous drop attacks. The study subjects were randomised to receive one of two two doses of cannabidiol, and their response was compared to a matched control group who were treated with placebo. The good news is that both doses of cannabidiol produced “greater reductions in the frequency of drop seizures than placebo”. Dispel the fear…and embrace the reefer!
This paper has nothing to do with why you can’t get that musical note out of your head, as revealed by the full title which is “Can’t get it off my brain: meta-analysis of neuroimaging studies on perseverative cognition”. But do not panic, at least not yet: perseverative cognition, it turns out, is just a fancy term for worrying or rumination. Published in the journal Psychiatry Research: Neuroimaging in 2020, the paper is a meta-analysis of 43 imaging studies of pathological worriers, those of us who have “intrusive, uncontrollable, repetitive thoughts”. To cut to the chase, and to avoid going round in circles, the centre of our rumination is a part of the brain called the anterior cingulate cortex (ACC). This structure, the authors said, is “critical for the pathological expression of rumination and worry”. You can now panic: you have the ACC to add to your list of things to worry about!
Visual snow syndrome is a relatively new thing for neurologists who are very much in the dark about it. From being a manifestation of migraine, it has climbed up the slippery disease classification ladder and is now a full-fledged syndrome of its own. It is therefore time for neurologists to see the light of visual snow, and what better way to show it than by such a catchy title. The paper, published in the journal Neurology in 2019, calls attention to this enigmatic phenomenon by providing a detailed review of the syndrome. But is the light bright enough for the neurologist?
Things that go twist in neurology are almost always dystonic, and this paper is no exception. Published in the journal Neurology Clinical Practice in 2019, the full title of the paper is “Sternocleidomastoid muscle hypertrophy in cervical dystonia: an unexpected twist”. It is a rather convoluted tale of a patient with Parkinson’s disease (PD) who developed cervical dystonia 10 days after he was treated with quetiapine. However, his sternocleidomastoid muscle was massively enlarged or hypertrophied, an impossible thing to happen within 10 days. You are beginning to get the twist. With their curiosity piqued, and their Sherlock Holmes hat on, the authors discovered that the patient has a previous history of dystonia, and the hypertrophy is really not as new as it first appeared. One surely for Agatha Christie fans, a tale with many unexpected twists. But the catchy title belies an important lesson- Occam’s razor doesn’t always cut sharply.
The idea that multiple sclerosis (MS), the quintessential white matter brain disease, is also a grey matter disease, is a bit of a shock to the traditional neurologist. The grave implication is that MS, the ultimate neuroinflammatory disease, is also a neurodegenerative disorder. This paradigm shift has all to do with the much better imaging tools available which show the grey matter changes in MS. And this editorial, published in the journal Nature in 2019, sums up the situation aptly, and catchily. The paper on which the editorial is based discusses how T cells interact with β-synuclein to cause the grey matter pathology in Lewis rats (rodents susceptible to experimental inflammatory diseases). Catchy editorials like this are doing a good job of taking us into the grey zone, and enabling us to see MS as much more than just relapses and progression.
If this headline doesn’t stop you in your tracks, then nothing ever will. The full title of this editorial is “Don’t just stand there: do something! The case for peri-ictal intervention”, and it comes from the journal Epilepsy Currents published in 2019. The paper it comments on, published in the journal Neurology in 2019, investigated the risk factors and best treatment for post-ictal hypoxaemia, that is low oxygen levels after generalised convulsions. It is not clear that the paper adds any new insights apart from stating the rather obvious fact that generalised convulsions lead to low blood oxygen levels. They however point out that the earlier oxygen is administered, the better the outcome. Not exactly groundbreaking research, but it resulted in an excellent catchy editorial.
This editorial, full title being “Heartbreakers-cardiac stress after uncomplicated generalized convulsive seizures”, is from the journal Epilepsy Currents published in 2019. And it is all about the risk of potentially fatal cardiac complications of epilepsy. The author was commenting on a paper published in the journal Epilepsia in 2019, which investigated the biomarkers of cardiac stress after a generalised convulsion. In essence, they were on the hunt for any red flags of fatal arrythmias, and of Takotsubo cardiomyopathy. And (you may insert drum roll here) the leading heartbreaker turned out to be… high‐sensitive troponin T (hsTNT). A catchy title to remind us that the heart is at risk in epilepsy.
Catchy titles help make the point. And there are more in the pipeline; the next in the series will look at catchy titles from the neurology archives. Watch this space, as they say.
It is no exaggeration to say that most progress in medicine has been achieved one unfortunate patient after another. Either by accident, or by misguided design, our understanding of human physiology and pathology have frequently come at the expense of the misfortune of countless patients, and it continues to do so. Whilst large trials teach us a lot about the characteristics of diseases, it is however the single case study that often reveals the most defining insights. For example, it was the accidental gunshot injury sustained by Alexis St Martinthat led to our understanding that the gastric phase of digestion depends on the acid produced by the stomach. The gory injury resulted in a permanent fistula between St Martin’s stomach and his skin, a veritable window through which the army doctor, William Beaumont, peered to see nature at work.
By Jesse Shire Myer – A book, Life and Letters of Dr. William Beaumont …, Public Domain, Link
But enough of other organs; our interest is of course the nervous system. Who then were the tragicheroes of neuroscience, the valiant who submitted their bodies in life, and their brains in death, for the advancement of science? Who are the famous, and the infamous, in the annals of the brain? Here is our run down of 7 remarkable patients who defined the history of neuroscience.
Patient SM is one of the lesser known figures in neuroscience, but her contribution to the science of emotions is immense. As someone who simply did not know what it was to experience fear, she provided the clues to the anatomical foundations of our passions. It turned out that the source of her fearlessness were lesions in her amygdala. It is little wonder that her life was characterised by risky ventures and perilous experiences, as she was incapable of detecting and avoiding danger. The amygdala is now established as the command and control centre for the emotions. One could argue, albeit unoriginally, that to lose one amygdala may be an accident, but to lose both will have to be termed a disaster. And in the case of Patient SM, her catastrophe is a result of Urbach–Wiethe disease, a disorder which destroys both amygdalas…but mercifully spares the hippocampus.
By Images are generated by Life Science Databases(LSDB). – from Anatomography, website maintained by Life Science Databases(LSDB).You can get this image through URL below. 次のアドレスからこのファイルで使用している画像を取得できますURL., CC BY-SA 2.1 jp, Link
Bertha Pappenheim, better known by her nickname ‘Anna O‘, was the seminal hysterical patient reported by Josef Breuer and Sigmund Freud. It is probably to her singular credit that the concept of hysteria became a neuroscience curiosity, even if this was on the fringes. Her constellation of symptomswill however befamiliar to every neurologist: limb paralysis, speech difficulties, visual impairment, hallucinations, and episodes of loss of consciousness. It is clear that this disorder lives on, and after several iterations, now comes under the remit of functional neurological disorders (FND). It is interesting that Freud had the largely correct insight that behind many cases of hysteria lies some form of trauma.
The great French neurologist Jean-Martin Charcot is not a person to be outdone by other neuroscientists, and this applies to his one-time protege, SigmundFreud. It is therefore not surprising that in studying hysteria, he outdid Freud by finding a more remarkable subject called Blanche Wittman. She became his star attraction in the demonstrations he held at the Pitié-Salpêtrière Hospital where she performed for the great and the good of French neurology. It is in this way that she achieved abiding fame in the iconic painting of Pierre Aristide André Brouillet. Her dramatic hysterical attacks earned her the sobriquet ‘The Queen of Hysterics‘, but her contribution to the actual science of the brain is rather underwhelming. There is however no denying that she is a lasting landmark in the history neuroscience.
4. Auguste Deter
By Unknown author – Unknown source, Public Domain, Link
Whilst the name Alois Alzheimer has gone down in history for describing the fearsome dementia that bears his name, the name of the patient who made it all possible is not a household one at all. Auguste Deter was the first person to be diagnosed with the horrendous disease which still ravages mankind, and without any cure in sight. After studying her illness in life, Alzheimer had the fortune of examining her brain after her death. It is his detailed examination that revealed what we now know as the hallmarks of the disease, senile plaques and neurofibrillary tangles. It is remarkable that a recent analysis of Alzheimer’s preserved histopathological slides revealed that Auguste Deter carried the classical presenilin 1 (PSEN1) gene mutation that is associated with the disease. Can neuroscience ever be any more satisfying than that!
3. Louis Victor Leborgne
By Polygon data were generated by Database Center for Life Science(DBCLS)[2]. – Polygon data are from BodyParts3D[1], CC BY-SA 2.1 jp, LinkYet another watershed neuroscience patient whose name doesn’t often ring any bells, or flow easily off the tongue. Leborgne’s misfortune was to develop a curious inability to speak, now recognised as expressive aphasia. He was only able to communicate with a single word, tan, and this explains his nickname, Patient Tan. Paul Broca’s fortune, on the other hand, was to study Leborgne in life, and to examine his brain after death. This singular patient made Broca a household name because this type of speech difficulty is also known as Broca’s aphasia. Broca also localised the lesion responsible for Leborgne’s aphasia, and it was in a part of the dominant hemisphere now known as Broca’s area. Two eponyms for the price of one you may say. Leborgne is also probably the turning point for the contentious concept of cerebral localisation, resurrecting it from the ashes of phrenology.
Phineas Gage is remarkable for achieving what few other neuroscience patient have, entry into popular folklore. The victim of a work-related accident, Gage sustained a unique form of brain injury when he was impaled by a tamping rod whilst trying to set explosions as part of his work as a rail construction worker. The explosion was accidentally set off prematurely, and the rod was propelled through Gage’s left cheek bone, through his left eye socket, and it then penetrated both frontal lobes. It was remarkable that Gage was not physically inconvenienced immediately following the accident, but surviving the whole affair was just the beginning of his real misfortune; his personality, previously calm and dedicated, became volatile and disinhibited. In relating the story of Gage, there is no getting away from a famous quotation; those who knew him before his accident pithily remarked that Gage ‘was no longer Gage‘. It is to his misfortune that we owe our understanding of the important role the frontal lobes play in regulating personality and behaviour.
1. Henry Molaison
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Known only as Patient HM throughout his life, Henry Gustav Molaison is perhaps the most important patient to ever cross the path of neuroscience. He earned this distinction on account of the profound amnesia he developed after he underwent brain surgery to control his severe epilepsy. Very bravely, his neurosurgeon, William Beecher Scoville, removed large chunks of his temporal lobes on both sides, a previously unheard of procedure. His epilepsy became largely controlled, but the aftermath was a disaster; he lost the ability to form new memories. As it has become a familiar refrain by now, Henry’s misfortune became a boon for neuroscience. He became probably the most extensively studied patient in the history of brain science; he spent the rest of his life undergoing one neuropsychological test or the other until neuroscientists obtained a thorough understanding of the anatomical and functional foundations of memory formation. Whilst the key lesson from his case is the important role of the hippocampus in memory formation, there is so much more he contributed to brain science in life. And even after death, his brain is an object of fascination for neuroscientists; they opened up his skull as soon as he died, took out his brain, and cut it up into tiny slices for further study. Henry is therefore the ultimate neuroscience patient who keeps giving even after departing this mortal coil.
Over the next few weeks I will be reviewing three excellent books on Henry Molaison in my book review blog, The Doctors Bookshelf. Why not follow me there to find out more about the remarkable man.
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Do you want to explore more interesting neuroscience patients?
I am yet to request serum neurofilament light protein (NfL) in my practice. I am not sure yet why I should, but until now I confess I really haven’t looked for a reason to do so. I however know that some MSologists now tick it, along with other blood tests, when they investigate people they suspect may have multiple sclerosis (MS). NfL are proteins that are released by damaged neurones. Should I be requesting NfL in my clinical practice? I sniffed around to find the case for testing serum NfL, and below is what I found.
Many studies have looked at the value of NfL in MS. One such very well-planned study that addresses many of my questions is that by Guili Disanto and colleagues, published in the journal Annals of Neurology in 2017. In the paper, titled Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis, the authors studied >380 people with MS and >150 healthy controls, and report four important findings.
The levels of NfL in serum strongly correlate with the levels in cerebrospinal fluid (CSF) of people with MS.
People with more active and more severe MS had higher levels of NfL.
People with MS on disease modifying treatment (DMT) had lower NfL levels than those who were not on treatment.
In people with MS who had their serum NfL tested serially over time, the level of NfL predicted those who will develop frequent relapses or progressive MS.
The authors concluded, with enough justification I think, that serum NfL is a “sensitive and clinically meaningful blood biomarker to monitor tissue damage and the effects of therapies in MS“.
The strong correlation between cerebrospinal fluid (CSF) and serum NfL was also confirmed by a study published in the journal Neurology, by Lenka Novakova and colleagues titled Monitoring disease activity in multiple sclerosis using serum neurofilament light protein. As the title indicates, they discovered that serum NfL is as good as CSF NfL in monitoring the progression of MS.
The observation that NfL predicts the course of MS is supported by many other studies, such as the one by Kristin Varhaug and colleagues in the journal Neurology Neuroimmunology and Neuroinflammation whose title is also self-explanatory: Neurofilament light chain predicts disease activity in relapsing-remitting MS. A more recent paper, also published in Neurology, further reinforces the benefit of serum NfL in disease course prediction. It is titled Blood neurofilament light chain as a biomarker of MS disease activity and treatment response. In this paper, Jehns Kuhle and colleagues practically confirm all the above stated benefits of NfL, concluding that “our results support the utility of blood NfL as an easily accessible biomarker of disease evolution and treatment response”.
As for long term outcome, the 10 year follow up study by Alok Bahn and colleagues, published in the Multiple Sclerosis Journal in 2018, is most informative. In their paper titled Neurofilaments and 10-year follow-up in multiple sclerosis, the authors noted that “CSF levels of NfL at the time of diagnosis seems to be an early predictive biomarker of long-term clinical outcome and conversion from RRMS to SPMS”. Further support for the long term prognostic value of serum NfL comes from a paper published in 2018 in the journal Brain titled Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis. The authors, Christian Barro and colleagues, studied more than 250 people with MS and concluded that “the higher the serum neurofilament light chain percentile level, the more pronounced was future brain and cervical spinal volume loss“.
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