What are the drugs promising neuroprotection in PD?

This is a follow up to my previous blog post titled The emerging research boosting Parkinson’s disease treatment. That post reviewed breakthroughs in the treatment of Parkinson’s disease (PD). But what are the advances in preventing the dreaded disease? What is the state of neuroprotection in PD? What are the hopes for attaining this elusive holy grail of neurology, the… Read More What are the drugs promising neuroprotection in PD?

30 neurological disorders with long ACRONYMS…and their checklists

Many neurological disorders and syndromes have very long and windy names. To bypass these tongue-twisting appellations, neurologists have become adept at coming up with great and catchy acronyms. Many neurological acronyms are very short, for example multiple sclerosis (MS), and Parkinosn’s disease (PD). Some are slightly longer, with three or four letters, for example frontotemporal… Read More 30 neurological disorders with long ACRONYMS…and their checklists

Is low vitamin D a cause of multiple sclerosis?

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk Rhead B, Bäärnhielm M, Gianfrancesco M, et al. Neurol Genet 2016; 2:e97. Abstract OBJECTIVE: We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject […]… Read More Is low vitamin D a cause of multiple sclerosis?

What is the relationship of pregnancy to myasthenia gravis?

Increased risk for clinical onset of myasthenia gravis during the postpartum period Boldingh MI, Maniaol AH, Brunborg C, Weedon-Fekjær H, Verschuuren JJ, Tallaksen CM. Neurology 2016; 87:2139-2145. Abstract OBJECTIVE: To study the risk of clinical onset of myasthenia gravis (MG) in pregnancy and during the first 6 months postpartum because an association between pregnancy or […]… Read More What is the relationship of pregnancy to myasthenia gravis?

Resolving the treatment conundrums of CIDP

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is as complicated to articulate, as it is to manage. CIDP is the result of an inflammatory attack against myelin, the fatty layer that encases large nerves. The damage to the myelin sheath considerably slows down the speed at which nerves transmit electrical impulses. This leads to limb weakness, sensory impairment,… Read More Resolving the treatment conundrums of CIDP

40 rare metabolic neurological disorders and their checklists

Metabolic neurological disorders are rare and complex. Their diagnosis requires deep knowledge and long experience. These characteristics make metabolic neurological disorders most amenable to checklists. Below are 40 metabolic neurological disorders which are all covered in Neurochecklists 4H syndrome Adrenoleukodystrophy Adult polyglucosan body disease Alexander disease Autophagic vacuolar myopathy Biotin responsive basal ganglia disease Canavan… Read More 40 rare metabolic neurological disorders and their checklists

How good is ocrelizumab for primary progressive MS?

  Ocrelizumab versus placebo in primary progressive multiple sclerosis Montalban X, Hauser SL, Kappos L, et al; ORATORIO Clinical Investigators. N Engl J Med 2016; doi: 10.1056/NEJMoa1606468 (Epub ahead of print). Abstract BACKGROUND: An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab,… Read More How good is ocrelizumab for primary progressive MS?