Migraine and the challenge of white matter lesions in the brain

Neurologists often refer their patients with headache for a brain MRI scan. Quite often the reason for this is to reassure their patients who are worried about a sinister cause for their headache…and the anxiety provoking culprit is usually a brain tumour. The headache is often a migraine which has recently changed in character, or which is defying… Read More Migraine and the challenge of white matter lesions in the brain

The remarkable disorders of the 12 cranial nerves…and their checklists

Nothing depicts the strange mix of beauty and complexity of the brain as the 12 pairs of cranial nerves. These nerves take off from the three sections of the brainstem and have intriguing names such as the olfactory, the trigeminal, the vestibulochochlear, and the hypoglossal. These magnificent twelve turn and twist, loop and meander, as… Read More The remarkable disorders of the 12 cranial nerves…and their checklists

What are the drugs in development for the treatment of epilepsy?

Progress report on new antiepileptic drugs: a summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS Epilepsia 2017; doi: 10.1111/epi.13634 (Epub ahead of print) Abstract The Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) took […]… Read More What are the drugs in development for the treatment of epilepsy?

Why is CLIPPERS breaking its shackles to the pons?

CLIPPERS is unusual enough you would think. Nothing to do with barbing and shearing I assure you. CLIPPERS stands for Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. The striking feature of CLIPPERS is inflammation in the pons, the chunky middle part of the brainstem. This distinguishes it from other neurological inflammatory disorders such… Read More Why is CLIPPERS breaking its shackles to the pons?

The A–Z of limb girdle muscular dystrophy (LGMD)

The muscular dystrophies are important inherited disorders of muscle. They are characterised by their sheer diversity, their multifaceted presentations, and their complicated diagnostic pathways. Some muscular dystrophies are relatively easy to recognise and diagnose. These include Duchenne’s muscular dystrophy (DMD), facio-scapulo-humeral muscular dystrophy (FSHD), myotonic dystrophy, and Emery Dreifuss muscular dystrophy (EDMD). In contrast, limb… Read More The A–Z of limb girdle muscular dystrophy (LGMD)

The emerging links between depression and MND

At first, it seemed like a single drop, but it is quickly turning into a trickle. The first inkling was a study of >1,700 people with motor neurone disease (MND) which was published in the journal Neurology titled Depression in amyotrophic lateral sclerosis. The authors found that depression is a very frequent diagnosis shortly before people are diagnosed with… Read More The emerging links between depression and MND

The 43 spinocerebellar ataxias: the complete checklists

Of all the disorders neurologists have to deal with, few have as many subtypes as spinocerebellar ataxia (SCA). Most neurologist are familiar with the more common SCAs-types 1,2,3,6, and 7. When pushed, SCA17 will pop into the mind…just because of its similarity to Huntington’s disease (HD). At the last count, there are 43 different forms… Read More The 43 spinocerebellar ataxias: the complete checklists