Is gadolinium necessary in multiple sclerosis follow up brain scans?

Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI Karimian-Jazi K, Wildemann B, Diem R, et al. Neurol Neuroimmunol Neuroinflamm 2018; 5:e480. Abstract OBJECTIVE: To assess the diagnostic value of gadolinium (Gd) contrast administration in MRI follow-up examinations of patients with MS if the T2 lesion load […]

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Is physical activity a risk factor for MND?

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. Visser AE, Rooney JPK, D’Ovidio F, et al; Euro-MOTOR consortium. JNNP 2018; 89:797-803. Abstract OBJECTIVE: To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case-control studies in three European countries using a validated and […]

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What factors predict bleeding from cerebral amyloid angiopathy?

The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. Rodrigues MA, Samarasekera N, Lerpiniere C, et al. Lancet Neurol 2018; 17:232-240. Abstract BACKGROUND: Identification of lobar spontaneous intracerebral haemorrhage associated with cerebral amyloid angiopathy (CAA) is important because it is associated […]

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Is measles infection a risk factor for brain tumours?

Measles may be a risk factor for malignant brain tumors. Lehrer S, Green S, Rendo A, Rosenzweig KE. Brain Tumor Res Treat 2015; 3:65-67. Abstract BACKGROUND: A possible risk factor for brain tumor might be measles, since late neurologic sequelae are part of measles pathology. Subacute sclerosing panencephalitis, a devastating neurologic illness, is prone to […]

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What is the radiological hallmark of secondary progressive MS?

Cervical spinal cord atrophy: an early marker of progressive MS onset. Zeydan B, Gu X, Atkinson EJ, et al. Neurol Neuroimmunol Neuroinflamm 2018; 5:e435. Abstract OBJECTIVE: To assess whether cervical spinal cord atrophy heralds the onset of progressive MS. METHODS: We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 patients with relapsing-remitting MS (RRMS) agematched to 25 patients within a year of onset of secondary […]

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How does endometriosis increase the risk of multiple sclerosis?

Identification of shared molecular signatures indicate the susceptibility of endometriosis to multiple sclerosis. Katiyar A, Sharma S, Singh TP, Kaur P. Front Genet 2018; 9:42. Abstract BACKGROUND: Women with endometriosis (EMS) appear to be at a higher risk of developing other autoimmune diseases predominantly multiple sclerosis (MS). Though EMS and MS are evidently diverse in […]

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How effective is aminophylline for post dural puncture headache?

Aminophylline for treatment of postdural puncture headache: a randomized clinical trial. Wu C, Guan D, Ren M, et al. Neurology 2018; 90:e1523-e1529. Abstract OBJECTIVE: To investigate the efficacy and safety of IV aminophylline for patients with postdural puncture headache (PDPH). METHODS: We randomly assigned patients to groups receiving either 250 mg IV aminophylline or a placebo within 3 hours of symptom […]

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