Autoimmune disorders are probably the most proliferative field of neurology. It seems like there is a blazing headline every week announcing a new antibody disease. Many of these antibodies are esoteric, but some shake the foundations of medical practice. Anti-MOG antibody is one of those which requires you to stop and pay attention, and it has significantly affected neurological practice in a very big way.
Perhaps the most important thing about anti-MOG antibody disease is that, like the chameleon, it presents in many guises. For the neurologist therefore, the first thing is to recognise these varied manifestations. Here then is a quick list of the 9 manifestations of anti MOG antibody disorder.
1. Optic neuritis (ON)
2. Neuromyelitis optica spectrum disorders (NMOSD)
3. Multiple sclerosis (MS)
4. Acute disseminated encephalomyelitis (ADEM)
5. Multiphasic disseminated encephalomyelitis (MDEM)
6. Isolated transverse myelitis (TM)
7. Leukodystrophy-like phenotype
8. Cerebral cortical encephalitis
9. Combined central and peripheral demyelinating syndrome (CCPD)
You can explore anti MOG antibody disorder further in Neurochecklists under the following titles:
For a detailed review and guidance, check this paper in Journal of Neuroinflammation: