More activity on the fringes of gluten neurology

I have dabbled into gluten neurology before with my post gluten neurology-persisting and growing? 

https://pixabay.com/en/wheat-field-wheat-cereals-grain-640960/
https://pixabay.com/en/wheat-field-wheat-cereals-grain-640960/

Prophetic it seems, as I am here forced to revisit the topic because  I came across a few recent interesting reports on the neurology of gluten.

Gluten psychosis

By Vincent van Gogh - bgEuwDxel93-Pg at Google Cultural Institute, zoom level maximum, Public Domain, Link
By Vincent van GoghbgEuwDxel93-Pg at Google Cultural Institute, zoom level maximum, Public Domain, Link

Take this case report from Nutrients titled gluten psychosis: confirmation of a new clinical entity. The article comes with some good references that suggest it will do no harm to check anti-gliadin antibodies in people with unexplained psychosis. I do wonder how one case report would confirm an entity such as gluten psychosis, but there you are.

Gluten-induced visual impairment

By OpenStax College - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013., CC BY 3.0, Link
By OpenStax College – Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, Jun 19, 2013., CC BY 3.0, Link

The second item is another case report published in Journal of Neurology titled severe, persistent visual impairment associated with occipital calcification and coeliac disease. The subject of the case report has long-standing coeliac disease and visual impairment. Her brain MRI scan showed calcifications in the visual area, evidence the authors claim, of celiac disease causing brain calcifications …..and thereby causing the patients visual loss. Is it just a case of correlation rather than causation? But there you are.

Gluten-induced motor neurone disease (MND)

Multiphoton microscopy of mouse motor neurons. ZEISS microscopy on Flikr. https://www.flickr.com/photos/zeissmicro/12174353194
Multiphoton microscopy of mouse motor neurons. ZEISS microscopy on Flikr. https://www.flickr.com/photos/zeissmicro/12174353194

The third report however pushes credulity to the limits. It is a review in Brain Blogger titled celiac disease and amyotrophic lateral sclerosis-is there a link? To its credit, the piece is heavily referenced; one such reference is from the American Journal of Neuroradiology  titled White Matter Lesions Suggestive of Amyotrophic Lateral Sclerosis Attributed to Celiac Disease. The thought is hard to bear, but there you are.

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By Photograph by Pdeitiker - Transferred from en.wikipedia to Commons., Public Domain, Link
By Photograph by Pdeitiker – Transferred from en.wikipedia to Commons., Public Domain, Link

What are your thoughts on the neurology of gluten? Please leave a comment

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Gluten neurology-persistent and growing?

Gluten neurology is a controversial issue, to say the least! The heated debates between Sheffield and Nottingham may lie in the fog of history, but the issue simmers just below the surface. Gluten sensitivity, or coeliac disease, is a big time player in other body systems, but its neurological manifestations are clouded in mystery.

Wheat: Gluten-rich "Wheat close-up" by User:Bluemoose - Own work. Licensed under ">CC BY-SA 3.0 via Wikimedia Commons.
Wheat: Gluten-rich
Wheat close-up” by User:BluemooseOwn work. Licensed under CC BY-SA 3.0 via Wikimedia Commons.

 

A lot of papers have ‘confirmed‘ a variety of neurological disorders associated with gluten sensitivity. These include even rare conditions such as progressive ataxia with palatal tremor. Other researchers have however struggled to find any relationship between gluten sensitivity and either ataxia or neuropathy.

Gluten neurology however keeps marching on, and the latest is gluten psychosisA single case report it is, published in Nutrients. And it brings the total number now to …2.

The debate goes on. In the meantime, it may just be prudent to check anti-gliadin antibodies in people with undiagnosed neurological conditions… before they are labelled idiopathic.

By Kurt Stueber - www.biolib.de, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=7487
By Kurt Stueber – www.biolib.de, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=7487