Autoimmune disorders are probably the most proliferative field of neurology. It seems like there is a blazing headline every week announcing a new antibody disease. Many of these antibodies are esoteric, but some shake the foundations of medical practice. Anti-MOG antibody is one of those which requires you to stop and pay attention, and it has significantly affected neurological practice in a very big way.
Perhaps the most important thing about anti-MOG antibody disease is that, like the chameleon, it presents in many guises. For the neurologist therefore, the first thing is to recognise these varied manifestations. Here then is a quick list of the 9 manifestations of anti MOG antibody disorder.
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1. Optic neuritis (ON)
2. Neuromyelitis optica spectrum disorders (NMOSD)
3. Multiple sclerosis (MS)
4. Acute disseminated encephalomyelitis (ADEM)
5. Multiphasic disseminated encephalomyelitis (MDEM)
6. Isolated transverse myelitis (TM)
7. Leukodystrophy-like phenotype
8. Cerebral cortical encephalitis
9. Combined central and peripheral demyelinating syndrome (CCPD)
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You can explore anti MOG antibody disorder further in Neurochecklists under the following titles:
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For a detailed review and guidance, check this paper in Journal of Neuroinflammation:
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing.
