The 20 most interesting neurological questions of 2017

Neurochecklists aims to simplify neurology… by striving to be comprehensive and current. To keep a close tab on everything neurological… We sifts through tens of journals and hundreds of studies. These studies enhance neurological practice… and highlight important points. They often challenge the conventional wisdom…. and regularly dispense with redundant dogmas. So what are the groundbreaking articles… that have tackled the big issues? Which are the papers pushing […]

via The 20 most interesting neurological questions of 2017 — Neurochecklists Updates

The most popular Neurochecklists blog posts in 2017

Neurochecklists Updates is just one year old. But it has recorded >20,000 visitors in this short time, racking up about 29,000 views! What has tickled people’s fancy in the last one year? What has caught their attention the most? Here are the most popular neurochecklists blog posts in 2017! Beach blogging. Mike Licht on Flikr. https://www.flickr.com/photos/notionscapital/2351382212 *** […]

via The most popular Neurochecklists blog posts in 2017 — Neurochecklists Updates

The 20 most viewed blog posts on The Neurology Lounge in 2017

The Neurology Lounge launched in August 2015. And it is now well into its third year2017 has been a busy one for the blog. It has surely been a hard slog. But with  >20,000 visitors. And >30,000 post views. It’s been well worth it.

Man blogging. Mike Licht on Flikr. https://www.flickr.com/photos/notionscapital/5031748151

Most posts have attracted encouraging attention. But some have done so more than others.

Two bloggers. Mike Licht on Flikr. https://www.flickr.com/photos/notionscapital/2744489459

So which were the 20 most viewed blog posts in 2017? Here is the countdown.

John Meynard Keynes blogging. Mike Licht on Flikr. https://www.flickr.com/photos/notionscapital/7276886256

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Join the journey; follow The Neurology Lounge in 2018.

Blogging when the children have gone to bed. Mike Licht on Flikr. https://www.flickr.com/photos/notionscapital/8479881057

Does high salt intake worsen disease progression in MS?

Sodium intake and multiple sclerosis activity and progression in BENEFIT Fitzgerald KC, Munger KL, Hartung HP, et al; BENEFIT Study Group. Ann Neurol 2017; 82:20-29. Abstract OBJECTIVE: To assess whether a high-salt diet, as measured by urinary sodium concentration, is associated with faster conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and MS […]

via Does high salt intake worsen disease progression in MS? — Neurochecklists Updates

Is polycystic kidney disease a risk factor for dementia?

Polycystic kidney disease is significantly associated with dementia risk. Yu TM, Chuang YW, Sun KT, et al. Neurology 2017; 89:1457-1463. Abstract OBJECTIVE: Data on the risk of neurodegenerative diseases, including Alzheimer disease (AD) and Parkinson disease (PD), in patients with polycystic kidney disease (PKD) are lacking. METHODS: A total of 4,229 patients who were aged […]

via Is polycystic kidney disease a risk factor for dementia? — Neurochecklists Updates

10 things we now know about CIDP associated with anti NF155 antibodies

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder which causes loss of the fatty myelin covering of large nerves (demyelination). This slows down the speed at which the nerves can transmit electrical impulses. People with CIDP develop weakness and sensory disturbances, but not always in equal measure. CIDP is a pain for the afflicted, and a veritable nightmare for the neurologist.

 

By AjimonthomasOwn work, CC BY-SA 4.0, Link

The diagnostic process for CIDP includes some rather uncomfortable tests such as nerve conduction studies and lumbar puncture (spinal tap). CIDP is however a most rewarding disease to treat because many people respond to immune treatments such as steroids, intravenous immunoglobulins (IVIG), or plasma exchange (PE).

PRED SOV 5. Leo Reynolds on Flikr. https://www.flickr.com/photos/lwr/3300474346

The diagnosis of CIDP is however not straightforward. The results of the tests are not always clearcut, and a lot of sifting and sorting goes into nailing the diagnosis. And even when the diagnosis is eventually made, there is a very long list of potential causes of CIDP which often require treatment on their own merit. Worryingly, some of these conditions make the treatment of CIDP difficult. And this is where IgG antibodies play a nasty role in CIDP.

By Database Center for Life Science (DBCLS), CC BY 3.0, Link

Neurologists are now recognising that a subset of people with CIDP have IgG4 antibodies which greatly influence the clinical presentation and the treatment of CIDP. Anti-contactin antibody is one such antibody, but by far the most important is anti-neurofascin 155 (NF155). What do we know about this antibody? How does it influence the course of CIDP? To answer these questions, below are 10 important things we now know about CIDP associated with anti-NF155.

By BruceBlausOwn work, CC BY-SA 4.0, Link

1. Anti-NF155 is an antibody to paranodal structures

2. The antibody is present in 7-14% of people with CIDP

3. CIDP with anti-NF155 usually affects young subjects

4. Anti NF155 antibody CIDP is usually severe

5. Anti NF155 may cause central nervous system inflammation 

6. It causes a very high protein level in the spinal fluid

7. It causes very severe changes on nerve conduction studies

8. It responds poorly to intravenous immunoglobulins (IVIg)

9. It may respond to steroids and plasma exchange

10. Treatment-resistant cases may respond to Rituximab
By Oguenther at de.wikipediaOwn work mit Jmol auf Basis RCSB PDB: 2OSL​., Public Domain, Link

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Why not check out everything CIDP on Neurochecklists:

Should people with myotonic dystrophy be counselled on the risk of cancer?

A population-based survey of risk for cancer in individuals diagnosed with myotonic dystrophy Abbott D, Johnson NE, Cannon-Albright LA Muscle Nerve 2016; 54:783-785. Abstract Introduction: The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population. Methods: Clinical data accessed from the largest Utah healthcare providers have been […]

via Should people with myotonic dystrophy be counselled on the risk of cancer? — Neurochecklists Updates

What factors predict the development of MS after the first attack of inflammation?

Multiple biomarkers improve the prediction of multiple sclerosis in clinically isolated syndromes Martinelli V, Dalla Costa G, Messina MJ, et al. Acta Neurol Scand 2017; 136:454-461. Abstract Objectives: Since its introduction, MRI had a major impact on the early and more precise diagnosis of multiple sclerosis (MS), and the 2010 diagnostic criteria even allow a […]

via What factors predict the development of MS after the first attack of inflammation? — Neurochecklists Updates