CLIPPERS is unusual enough you would think. Nothing to do with barbing and shearing I assure you. CLIPPERS stands for Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. The striking feature of CLIPPERS is inflammation in the pons, the chunky middle part of the brainstem. This distinguishes it from other neurological inflammatory disorders such as multiple sclerosis (MS) and neuromyelitis optica (NMO).
CLIPPERS has however now broken loose from its shackles to the pons, and is spreading down into the spinal cord. Sacrilege you might say.
This disruptive and subvertive action was reported in two prestigious neurology journals. The first paper in the journal, Neurology, is titled CLIPPERS with diffuse white matter and longitudinally extensive spinal cord involvement. The second is reported in the journal, Brain, as CLIPPERS with lesions distributed predominantly in spinal cord.
What is it about neurological inflammatory disorders that makes them so rebellious? Why do they defy convention and disregard their defining features. I discussed a similar phenomenon in my previous blog post titled Why is neuromyelitis optica (NMO) endlessly surprising neurology? NMO refused to play by the rules and was punished by having it’s named changed to NMOSD. Perhaps it’s time for CLIPPERS to suffer the same fate….starting with a shorter acronym perhaps?
Check out more on CLIPPERS in Neurochecklists