How good is ocrelizumab for primary progressive MS?

 

B0007277 Monoclonal antibodies Credit: Anna Tanczos. Wellcome Images images@wellcome.ac.uk http://images.wellcome.ac.uk
B0007277 Monoclonal antibodies
Credit: Anna Tanczos. Wellcome Images
images@wellcome.ac.uk
http://images.wellcome.ac.uk

Ocrelizumab versus placebo in primary progressive multiple sclerosis Montalban X, Hauser SL, Kappos L, et al; ORATORIO Clinical Investigators. N Engl J Med 2016; doi: 10.1056/NEJMoa1606468 (Epub ahead of print). Abstract BACKGROUND: An evolving understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a […]

via How good is ocrelizumab for primary progressive MS? — Neurochecklists Updates

40 very handy and practical neurochecklists

Neurochecklists now contains >1600 checklists on all aspects of neurology. Many checklists come to the rescue only to fill a knowledge gap. Most neurochecklists however address important practical questions or outline pragmatic steps in managing neurological disorders. To illustrate, below is a selection of 40 handy neurochecklists *** Anticoagulants: bridging therapy for surgery Antiepileptic drugs (AEDs): choice […]

via 40 very handy and practical neurochecklists — Neurochecklists Updates

What are the emerging drug treatments for Parkinson’s disease (2)?

Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with parkinson disease and motor fluctuations: a randomized clinical trial Schapira AH, Fox SH, Hauser RA, et al. JAMA Neurol 2016; doi: 10.1001/jamaneurol.2016.4467 (Epub ahead of print). Abstract IMPORTANCE: Although levodopa remains the most effective oral pharmacotherapy for Parkinson disease (PD), its […]

via What are the emerging drug treatments for Parkinson’s disease (2)? — Neurochecklists Updates

How do tortuous blood vessels predispose to cervical artery dissection?

By Henry Vandyke Carter - Henry Gray (1918) Anatomy of the Human Body (See "Book" section below)Bartleby.com: Gray's Anatomy, Plate 1210, Public Domain, Link
By Henry Vandyke CarterHenry Gray (1918) Anatomy of the Human Body (See “Book” section below)Bartleby.com: Gray’s Anatomy, Plate 1210, Public Domain, Link

 

Dissection is an increasingly recognized cause of ischemic stroke, which occurs spontaneously or after trauma, in relatively young patients. We hypothesized that there might be a predisposing factor weakening the vascular wall and […]

via How do tortuous blood vessels predispose to cervical artery dissection? — Neurochecklists Updates

What were the most popular posts on The Neurology Lounge in 2016?

The Neurology Lounge started in July 2015 and it is now well into its 2nd year. 2016 was the first complete 12-month calendar period, and during this time the blog received about 25,000 visits and just under 40,000 views.

Keyboard cat. Cassandra Leigh Gotto on Flikr https://www.flickr.com/photos/threecheersformcr_xo/5340309206
Keyboard cat. Cassandra Leigh Gotto on Flikr https://www.flickr.com/photos/threecheersformcr_xo/5340309206

There were visitors from >150 countries around the world with the United States recording the most visits at just under 15,000, followed closely by the United Kingdom with about 5,000. There were >1,000 visitors each from Canada, Australia, Spain and India. Engagement however remains disappointingly low with only 117 comments and 67 likes.

Blog dog. Håkan Dahlström on Flikr. https://www.flickr.com/photos/dahlstroms/5499898533
Blog dog. Håkan Dahlström on Flikr. https://www.flickr.com/photos/dahlstroms/5499898533

Some topics attracted more interest than others, sometimes surprisingly so. Below is the countdown of the 15 most viewed posts on The Neurology Lounge in 2016.

 

15. Top all-time neurology review articles

14. How to keep your distance from a neurologist

13. How bright is the future for Alzheimer’s disease?

12. Proven all-time outstanding neurology textbooks

11. What are the most controversial questions in neurology?

10. What’s evolving at the cutting-edge of autoimmune neurology?

9. Keeping up with the latest practical guidelines in neurology

8. Are these the all-time most influential Neurologists?

7. Which are the most useful neurological applications?

6. What are the dreadful autoimmune disorders that plague neurology?

5. The emerging research boosting Parkinson’s disease treatment

4. Masitinib, a breakthrough drug shattering neurology boundaries

3. Outstanding neurology video channels

2. Is neurology research finally breaking the resolve of MND?

1. 7 ominous signs that suggest you need to see a neurologist 

https://pixabay.com/en/blog-leave-texts-blogger-blogging-1027861/
https://pixabay.com/en/blog-leave-texts-blogger-blogging-1027861/

 

The statistics are encouraging enough for The Neurology Lounge to carry on through 2017!

 

What are the emerging drug treatments for Parkinson’s disease (1)

Opicapone as an adjunct to levodopa in patients with Parkinson’s disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial Ferreira JJ, Lees A, Rocha JF, et al; Bi-Park 1 investigators. Lancet Neurol 2016; 15:154-165 Abstract BACKGROUND: Opicapone is a novel, once-daily, potent third-generation catechol-O-methyltransferase inhibitor. We aimed to assess the safety and efficacy of […]

via What are the emerging drug treatments for Parkinson’s disease (1)? — Neurochecklists Updates

10 revised and refreshed neurochecklists

Neurochecklists is in a continuous process of improvement and enhancement. To do so, it keeps up with the latest neurology articles and reviews, and stays on top of the latest guidelines and current trends. And these are churned out by the minute. In the Neurochecklists spirit of comprehensiveness and recency, below are 10 recent checklists which have been revised […]

via 10 revised and refreshed neurochecklists (1) — Neurochecklists Updates