Myasthenia gravis (MG) is one of the best characterised neurological disorders. The hallmark of MG is fatigable weakness. This manifests as intermittent ptosis (droopy eyelids), diplopia (double vision), and limb weakness. There are two main types-ocular MG affects just the eyes and eyelids, and generalised MG affects the body, including the bulbar functions of breathing and swallowing. The problem in MG is straightforward… Read More How is innovative neurology research energising myasthenia?
Charcot Marie Tooth disease (CMT) is the most important inherited peripheral neuropathy. As with most genetic diseases, there is no cure for CMT. The best neurologists can offer at the moment is supportive treatment for complications of CMT such as foot drop and foot deformities. Neurologists are however very keen to go beyond platitudes and ankle supports for their… Read More Will a pill really hold the cure for CMT?
Multiple system atrophy (MSA) is a mimic of Parkinson’s disease (PD). Neurologists suspect MSA in people with apparent PD who, in addition, have other defining features. In many people with MSA their prominent symptoms are cerebellar dysfunction (MSA-C), and these have unsteadiness and incoordination of movements. In other people with MSA the predominant symptoms are of Parkinsonism, and this type… Read More What’s happening at the cutting edge of MSA?
Neurologists are always cautious when making a diagnosis of Parkinson’s disease (PD). This shouldn’t be the case because PD is not difficult to recognise-at least not most of the time. For one, PD has classical clinical signs- the trio of resting tremor, slow movements (bradykinesia), and stiffness (rigidity). For another, it is asymmetrical, starting and remaining worse on one side of the body.… Read More What is the state of Parkinson’s disease biomarkers?
Neurologists do not break into a sweat when they make the diagnosis of essential tremor (ET). Theoretically, at least, they shouldn’t. Essential tremor presents with an obvious shaking of the hands when performing tasks; this is unlike the tremor of Parkinson’s disease which is typically at rest. Neurologists also have handy evidence-based treatment guidelines which recommend medications such as Propranolol and Primidone. … Read More What precisely is the driver for essential tremor?
Duchenne muscular dystrophy (DMD) is the most familiar of the inherited muscle diseases called muscular dystrophies. DMD is life limiting, but advances in care are enabling children born with this disease to survive well into adulthood. The disease is named after the French neurologist Guillaume Duchenne. The foundation of long survival in DMD is close… Read More How is neurology stamping out the anguish of Duchenne?