Metronidazole-two case lessons for neurologists

I came across two articles recently which highlighted neurological complications of metronidazole I was previously unaware of.

321-Metronidazole by Chris on Flikr. https://www.flickr.com/photos/chrisinplymouth/3947569729
321-Metronidazole by Chris on Flikr. https://www.flickr.com/photos/chrisinplymouth/3947569729

 

The first is a case report of metronidazole-induced encephalopathy in the journal Neurocritical Care. I admit I only read the abstract and the key word there is involvement of the dentate nuclei.

 

Metronidazole by Chris on Flikr. https://www.flickr.com/photos/chrisinplymouth/3949517597/
Metronidazole by Chris on Flikr. https://www.flickr.com/photos/chrisinplymouth/3949517597/

 

The second case report is of metronidazole-induced ataxia in the journal Movement Disorders.

 

These are rather uncommon side-effects and should not deter from prescribing metronidazole. But it is just worth looking more carefully at that medication list if your next patient  has unexplained encephalopathy or ataxia.

 

 

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